2025 (Current Year) Faculty Courses School of Life Science and Technology Undergraduate major in Life Science and Technology
Enzyme Engineering
- Academic unit or major
- Undergraduate major in Life Science and Technology
- Instructor(s)
- Tomoko Matsuda / Tetsuya Kitaguchi / Shunichiro Ogura
- Class Format
- Lecture (Face-to-face)
- Media-enhanced courses
- -
- Day of week/Period
(Classrooms) - 3-4 Tue / 3-4 Fri
- Class
- -
- Course Code
- LST.A364
- Number of credits
- 200
- Course offered
- 2025
- Offered quarter
- 1Q
- Syllabus updated
- Apr 3, 2025
- Language
- Japanese
Syllabus
Course overview and goals
Catalysts for reactions occurring in all living organisms are enzymes, so the understanding of the properties and functions of enzymes is indispensable for the understanding of life science and technology. This course covers the basics and applications concerning enzymes. The knowledge of biochemistry and organic chemistry will be applied to understand enzymes. The cutting-edge research using enzymes in the field of the medicinal, food, and environmental sciences, as well as organic chemistry, is also introduced. Furthermore, the opportunities to discuss, communicate and present about the field of studies are given.
The lectures about the enzyme improve your logical thinking ability, communication, and presentation skills as well as help your acquirement of technical knowledge. It is to cultivate the human resources that can lead advanced science and engineering through the studies of enzymes.
Course description and aims
By the end of this course, students will be able to:
(1) Acquire the basic knowledge about enzymes and enzyme kinetics. Understand the applied studies of bioengineering related to enzyme.
(2) Acquire the knowledge about enzymes controlling metabolism. Understand the effect of the enzymes on the diseases.
(3) Acquire the knowledge about application of enzymes to organic chemistry.
(4) Understand and present the recent research using enzymes in organic synthesis.
Keywords
enzyme, enzyme kinetics,
enzymes controlling metabolism,
hydrolase, oxidoreductase, coenzyme
Competencies
- Specialist skills
- Intercultural skills
- Communication skills
- Critical thinking skills
- Practical and/or problem-solving skills
Class flow
Classes by Ogura, Kitaguchi and Ichinose will be lecture-style ones. Classes by Matsuda are interactive, and there are also group discussion opportunity. Presentation may be required at the classes by Matsuda.
Course schedule/Objectives
| Course schedule | Objectives | |
|---|---|---|
| Class 1 | Basics of enzymes (Ogura) | Acquire the knowledge of basics of enzyme through general introduction |
| Class 2 | Enzymes used in the laboratory (Ogura) | Acquire the knowledge of enzymes used in the laboratory |
| Class 3 | Energy and drug metabolizing enzymes (Ogura) | Acquire the knowledge of energy and drug metabolizing enzymes |
| Class 4 | Proteolytic enzymes and homeostasis (Ogura) | Acquire the knowledge of Proteolytic enzymes and homeostasis |
| Class 5 | Enzyme and protein engineering (Kitaguchi) | Acquire knowledge of enzyme modification through protein engineering |
| Class 6 | Physiological significance of the enzymes and the diseases caused by the dysfunction of the enzyme (Ichinose) | Understand the physiological significance of the enzymes to maintain homeostasis, and the etiology of the diseases caused by the dysfunction of the enzyme |
| Class 7 | Enzyme and intracellular signal transduction (Kitaguchi) | Acquire knowledge of intracellular signaling involving enzymes |
| Class 8 | Enzyme and disease (Kitaguchi) | Acquire knowledge of how genetic mutations in enzymes cause disease |
| Class 9 | Understanding enzymes with organic chemistry aspect (Matsuda) | Apply the knowledge of organic chemistry to understand enzyme properties and function |
| Class 10 | Application of enzymes in the field of organic chemistry (Matsuda) | Understand the applied studies of enzymes in organic chemistry |
| Class 11 | Reaction mechanisms of hydrolase (Matsuda) | Understand the mechanism of hydrolase |
| Class 12 | Reaction mechanisms of oxidoreductase (Matsuda) | Understand the mechanism of oxidoreductase functioning with coenzyme |
| Class 13 | Presentation (Matsuda) | Group presentation and discussion |
| Class 14 | Backup day | Backup day |
Study advice (preparation and review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to course materials.
Textbook(s)
Handout
Reference books, course materials, etc.
Handout
Evaluation methods and criteria
Students' abilities to understand the basics of enzyme engineering and their abilities to apply the basics to study enzyme and develop enzyme engineering will be assessed.
Class participation, report and quiz 1 during classes by Ogura (31%)
Class participation, report by Kitaguchi (23%)
Class participation, report by Ichinose (8%)
Class participation, presentation and report during classes by Matsuda (38%)
Related courses
- Organic chemistry I〜 IV
- Phisical chemistry I〜 III
- Biochemistry I, II
Prerequisites
None