2025 (Current Year) Faculty Courses School of Materials and Chemical Technology Department of Chemical Science and Engineering Graduate major in Chemical Science and Engineering
Advanced Biofunctional Chemistry II
- Academic unit or major
- Graduate major in Chemical Science and Engineering
- Instructor(s)
- Katsunori Tanaka
- Class Format
- Lecture
- Media-enhanced courses
- -
- Day of week/Period
(Classrooms) - Class
- -
- Course Code
- CAP.A426
- Number of credits
- 100
- Course offered
- 2025
- Offered quarter
- 4Q
- Syllabus updated
- Mar 19, 2025
- Language
- English
Syllabus
Course overview and goals
In this lecture, I will explain how the chemistry-based technologies, especially focusing on the synthetic organic chemistry, are applied to understand and regulate the biologically important processes. Especially, in "Advanced Biofunctional Chemistry II", the recent application to drug development, diagnostic and therapeutic fields will be studied.
Course description and aims
By taking this lecture, students will understand the following technologies applied to the clinical fields using synthetic organic chemistry.
(1) Labeling and bioconjugation
(2) Molecular imaging
(3) Understanding the in cell functions
(4) Activation of biologically active compounds and drugs
Keywords
Synthetic organic chemistry, molecular imaging, labeling, bioconjugation, in cell functions, biologically active compounds, drugs
Competencies
- Specialist skills
- Intercultural skills
- Communication skills
- Critical thinking skills
- Practical and/or problem-solving skills
Class flow
This lecture proceed in the order of (1) labeling and bioconjugation, (2) molecular imaging, (3) understanding the in cell functions, and (4) activation of biologically active compounds and drugs, as the new synthesis-based technologies for clinical applications. In the last round, exercises and commentary for confirming comprehension degree will be implemented.
Course schedule/Objectives
| Course schedule | Objectives | |
|---|---|---|
| Class 1 | Synthetic technology for labeling and bioconjugation | Explain the application of labeling and bioconjugation. |
| Class 2 | Synthetic technology for labeling and bioconjugation | Explain the application of labeling and bioconjugation. |
| Class 3 | Synthetic technology for molecular imaging | Explain the application of molecular imaging. |
| Class 4 | Synthetic technology for understanding the in cell functions | Explain the synthetic application for understanding the in cell functions. |
| Class 5 | Synthetic technology for activation of biologically active compounds and drugs | Explain the synthetic application for activation of biologically active compounds and drugs. |
| Class 6 | Synthetic technology for activation of biologically active compounds and drugs | Explain the synthetic application for activation of biologically active compounds and drugs. |
| Class 7 | Practice problems and interpretation for confirming the level of understanding | Solve practice problems by accurate understanding of the above all lectures. |
Study advice (preparation and review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
Although the lecture will be delivered on the basis of the following book, the reference materials will be delivered in advance and/or during each lecture.
Tanaka, K. and Vong, K., Handbook of In Vivo Chemistry in Mice: From Lab to Living System (Wiley-VCH) ISBN: 978-3-527-34432-1
Reference books, course materials, etc.
The additional materials will be delivered in advance and/or during each lecture.
Evaluation methods and criteria
Practice problems and interpretation for confirming the level of understanding (90%), level of class participation (10%) (The level of class participation will be calculated by discussion, small examination and so on in the lecture).
Related courses
- CAP.O201 ： Organic Chemistry I(Alkanes, Alkenes, Alkynes)
- CAP.O202 ： Organic Chemistry II(C-X)
- CAP.O203 ： Organic Chemistry III(Benzene・C-O)
- CAP.O204 ： Organic Chemistry IV（C=O・C≡N)
- CAP.O301 ： Synthetic Organic Chemistry(C=0 Substitution・Condensation・C-N・Cyclic Reaction)
- CAP.O302 ： Bioorganic Chemistry (Bioactive Small-Molecules)
- CAP.A425 ： Advanced Biofunctional Chemistry I
Prerequisites
Although there are no conditions for taking this course, it is desirable to take Organic Chemistry first to fourth, Synthetic Organic Chemistry, Bioorganic Chemistry, as well as Advanced Biofunctional Chemistry I.