2025 (Current Year) Faculty Courses School of Materials and Chemical Technology Department of Chemical Science and Engineering Graduate major in Chemical Science and Engineering
Advanced Organometallic Chemistry and Catalysis II
- Academic unit or major
- Graduate major in Chemical Science and Engineering
- Instructor(s)
- Ken Tanaka
- Class Format
- Lecture
- Media-enhanced courses
- -
- Day of week/Period
(Classrooms) - Class
- -
- Course Code
- CAP.T432
- Number of credits
- 100
- Course offered
- 2025
- Offered quarter
- 4Q
- Syllabus updated
- Mar 19, 2025
- Language
- English
Syllabus
Course overview and goals
[Summary of the lecture] In this lecture, "reactions via allyl metal complexes (isomerization and allylic substitution reactions)", "reactions via carbene complexes (cyclopropanation and metathesis reactions)", "reactions via metallacycles (cycloaddition and cycloisomerization reactions)", and "reactions via electrophilic activation of unsaturated bonds (functionalization reactions of alkenes and alkynes)", which are particularly important for the application to organic synthesis in the organometallic catalyst chemistry, will be explained.
[Aim of the lecture] The organometallic catalysis chemistry is extremely important in not only laboratory organic synthesis but also industrial organic synthesis. In this lecture, various catalyses are classified and explained by the reaction mechanism. In addition, the development of asymmetric variants and application of these catalyses to the industrial synthesis of organic fine chemicals will also be introduced. Finally, students acquire the ability to apply organometallic catalysis to organic synthesis.
Course description and aims
By the end of this course, students acquire the following ability:
(1) Ability to explain "reactions via allyl metal complexes ".
(2) Ability to explain "reactions via carbene complexes".
(3) Ability to explain "reactions via metallacycles".
(4) Ability to explain "reactions via electrophilic activation of unsaturated bonds".
(5) Ability to apply organometallic catalysis (1)-(4) to organic synthesis.
Keywords
Reactions via allyl metal complexes, allylic substitution reactions, isomerization reactions, reactions via carbene complexes, cyclopropanation reactions, metathesis reactions, reactions via metallacycles, cycloaddition reactions, cycloisomerization reactions, reactions via electrophilic activation of unsaturated bonds, functionalization reactions of alkenes, functionalization reactions of alkynes
Competencies
- Specialist skills
- Intercultural skills
- Communication skills
- Critical thinking skills
- Practical and/or problem-solving skills
Class flow
This lecture will proceed in the following order: "reactions via allyl metal complexes", "reactions via carbene complexes", "reactions via metallacycles", and "reactions via electrophilic activation of unsaturated bonds". In addition, the development of asymmetric variants and application of these catalyses to the industrial synthesis of organic fine chemicals will also be introduced. In the last day, practice problems and interpretation of them will be carried out to confirm the level of understanding.
Course schedule/Objectives
| Course schedule | Objectives | |
|---|---|---|
| Class 1 | Reactions via allyl metal complexes (1): allylic substitution reactions | Explain the allylic substitution reactions. |
| Class 2 | Reactions via allyl metal complexes (2): isomerization reactions | Explain the isomerization reactions. |
| Class 3 | Reactions via carbene complexes: cyclopropanation reactions, metathesis reactions | Explain the cyclopropanation reactions and metathesis reactions. |
| Class 4 | Reactions via electrophilic activation of unsaturated bonds (1): functionalization reactions of alkenes | Explain the functionalization reactions of alkenes. |
| Class 5 | Reactions via electrophilic activation of unsaturated bonds (2): functionalization reactions of alkynes | Explain the functionalization reactions of alkynes. |
| Class 6 | Reactions via metallacycles: cycloisomerization and cycloaddition reactions | Explain the cycloisomerization and cycloaddition reactions. |
| Class 7 | Practice problems and interpretation for confirming the level of understanding | Solve practice problems by accurate understanding of the above all lectures. |
Study advice (preparation and review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
undecided
Reference books, course materials, etc.
Lecture materials will be distributed at each session.
参考書：化学の要点シリーズ６：有機金属化学 日本化学会・垣内史敏 共立出版
Evaluation methods and criteria
In-person written test not to be brought in
Related courses
- CAP.A561 ： Advanced Chemistry of Transition Metal Complexes I
- CAP.A562 ： Advanced Chemistry of Transition Metal Complexes II
- CAP.I403 ： Advanced Coordination Chemistry
- CAP.A463 ： Advanced Molecular Design of Metal Complexes I
- CAP.A464 ： Advanced Molecular Design of Metal Complexes II
Prerequisites
The condition of the study will not be made, but it is desirable to study Advanced Chemistry of Transition Metal Complexes I & II,
Advanced Molecular Design of Metal Complexes I & II, or Advanced Coordination Chemistry.
Other
This course can not be taken at the same time as CAP.I439"Organometallic Catalyst Chemistry".