2025 (Current Year) Faculty Courses School of Materials and Chemical Technology Department of Chemical Science and Engineering Graduate major in Chemical Science and Engineering
Advanced Organometallic Chemistry and Catalysis I
- Academic unit or major
- Graduate major in Chemical Science and Engineering
- Instructor(s)
- Ken Tanaka
- Class Format
- Lecture
- Media-enhanced courses
- -
- Day of week/Period
(Classrooms) - Class
- -
- Course Code
- CAP.T431
- Number of credits
- 100
- Course offered
- 2025
- Offered quarter
- 3Q
- Syllabus updated
- Mar 19, 2025
- Language
- English
Syllabus
Course overview and goals
[Summary of the course]
The instructor explains "reduction reactions (hydrogenation reactions, hydrosilylation reactions, and hydroboration reactions)", "oxidation reactions (epoxidation reactions, dihydroxylation reactions, and dehydrogenation reactions)", and "coupling reactions (carbon-carbon bond forming reactions, carbon-heteroatom bond forming reactions, carbonylation reactions, and carbon-hydrogen bond activation reactions)", which are especially important for applications to organic synthesis within organometallic catalyst chemistry.
[Aim of the course]
Organometallic catalysis chemistry is extremely important in not only laboratory organic synthesis but also industrial organic synthesis. In this course, various catalysis are classified and explained by the reaction mechanism. In addition, the development of catalytic asymmetric synthesis and application of these catalysis to the industrial synthesis of organic fine chemicals will also be introduced. Finally, students acquire the ability to apply organometallic catalysis to organic synthesis.
Course description and aims
By the end of this course, students acquire the following ability:
(1) Ability to explain "reduction reactions" (hydrogenation reactions, hydrosilylation reactions, and hydroboration reactions).
(2) Ability to explain "oxidation reactions" (epoxidation reactions, dihydroxylation reactions, and dehydrogenation reactions).
(3) Ability to explain "coupling reactions" (carbon-carbon-bond forming reactions, carbon-heteroatom bond forming reactions, carbonylation reactions, and carbon-hydrogen bond activation reactions).
(4) Ability to apply organometallic catalysis (1)-(3) to organic synthesis.
Keywords
Reduction reactions, hydrogenation reactions, hydrosilylation reactions, hydroboration reactions, oxidation reactions, epoxidation reactions, dihydroxylation reactions, dehydrogenation reactions, coupling reactions, carbon-carbon bond forming reactions, carbon-heteroatom bond forming reactions, carbonylation reactions, carbon-hydrogen bond activation reactions
Competencies
- Specialist skills
- Intercultural skills
- Communication skills
- Critical thinking skills
- Practical and/or problem-solving skills
Class flow
This course covers reduction reactions, oxidation reactions, and coupling reactions, in that order. The instructor will also introduce examples of the catalytic asymmetric synthesis of optically active compounds, and examples of applying it to the industrial synthesis of organic fine chemicals as the need arises. In the final class, exercises and commentaries will be conducted to check understanding.
Course schedule/Objectives
| Course schedule | Objectives | |
|---|---|---|
| Class 1 | Reduction reaction (1): Hydrogenation reactions | Explain the hydrogenation reaction. |
| Class 2 | Reduction reaction (2): Hydrosilylation reactions, hydroboration reactions | Explain the hydrosilylation and hydroboration reactions. |
| Class 3 | Oxidation reaction: Epoxidation reactions, dihydroxylation reactions, dehydrogenation reactions | Explain the epoxidation, dihydroxylation, and dehydrogenation reactions. |
| Class 4 | Coupling reactions (1): Carbon-carbon and carbon-heteroatom bond forming reactions | Explain the carbon-carbon and carbon-heteroatom bond forming coupling reactions. |
| Class 5 | Coupling reactions (2): Carbonylation reactions | Explain the carbonylation reaction. |
| Class 6 | Coupling reactions (3): Carbon-hydrogen bond activation reactions | Explain the carbon-hydrogen bond activation reaction. |
| Class 7 | Exercises and explanations for checking the students' understandings | Solve practice problems by accurate understanding of the above all lectures. |
Study advice (preparation and review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
undecided
Reference books, course materials, etc.
Lecture materials will be distributed at each session.
参考書：化学の要点シリーズ６：有機金属化学 日本化学会・垣内史敏 共立出版
Evaluation methods and criteria
In-person written test not to be brought in
Related courses
- CAP.A561 ： Advanced Chemistry of Transition Metal Complexes I
- CAP.A562 ： Advanced Chemistry of Transition Metal Complexes II
- CAP.I403 ： Advanced Coordination Chemistry
- CAP.A463 ： Advanced Molecular Design of Metal Complexes I
- CAP.A464 ： Advanced Molecular Design of Metal Complexes II
Prerequisites
The condition of the study will not be made, but it is desirable to study Advanced Chemistry of Transition Metal Complexes I & II,
Advanced Molecular Design of Metal Complexes I & II, or Advanced Coordination Chemistry.
Contact information (e-mail and phone) Notice : Please replace from ”[at]” to ”@”(half-width character).
Ken Tanaka: ktanaka[at]apc.titech.ac.jp
Other
This course can not be taken at the same time as CAP.I 439 "Organometallic Catalyst Chemistry".