2025 (Current Year) Faculty Courses School of Science Department of Chemistry Graduate major in Chemistry
Advanced Organic Synthesis
- Academic unit or major
- Graduate major in Chemistry
- Instructor(s)
- Ken Ohmori / Yoshio Ando
- Class Format
- Lecture (Livestream)
- Media-enhanced courses
- -
- Day of week/Period
(Classrooms) - 3-4 Mon / 3-4 Thu
- Class
- -
- Course Code
- CHM.D432
- Number of credits
- 200
- Course offered
- 2025
- Offered quarter
- 2Q
- Syllabus updated
- Mar 19, 2025
- Language
- English
Syllabus
Course overview and goals
On Mondays, the retrosynthetic analysis of functional compounds and strategies for the multi-step synthesis of natural organic compounds will be explained.
On Thursdays, the basic theory of pericyclic reactions widely used in organic synthesis, their applications and practical examples will be discussed.
Course description and aims
At the end of this course, students will be able to have an understanding of basic concept of retrosynthesis and pricyclic reactions, enabling access to complex functional compounds and also natural products.
Keywords
multistep synthesis
retrosynthesis
natural product synthesis
Competencies
- Specialist skills
- Intercultural skills
- Communication skills
- Critical thinking skills
- Practical and/or problem-solving skills
Class flow
This course will be conducted online and will include a group discussions and presentations by students.
Course schedule/Objectives
| Course schedule | Objectives | |
|---|---|---|
| Class 1 | Basic concept of retrosynthesis | Exercise problems might be given in this class. |
| Class 2 | Overview of the pericyclic reactions | Exercise problems might be given in this class. |
| Class 3 | Functional group transformation, addition, and migratory functional group introduction in retrosynthesis | Exercise problems might be given in this class. |
| Class 4 | Cycloaddition 1 | Exercise problems might be given in this class. |
| Class 5 | Synthetic strategies for the construction of optically active compounds | Exercise problems might be given in this class. |
| Class 6 | Cycloaddition 2 | Exercise problems might be given in this class. |
| Class 7 | Synthetic strategies based on skeletal rearrangements and cascade bond formation | Exercise problems might be given in this class. |
| Class 8 | Woodward–Hoffmann rule | Exercise problems might be given in this class. |
| Class 9 | Group discussion and presentation on multi-step synthesis plan for organic compounds | Exercise problems might be given in this class. |
| Class 10 | Electrocyclic reaction | Exercise problems might be given in this class. |
| Class 11 | Synthesis of terpenoids | Exercise problems might be given in this class. |
| Class 12 | Sigmatropic rearrangement | Exercise problems might be given in this class. |
| Class 13 | Synthesis of alkaloids | Exercise problems might be given in this class. |
| Class 14 | Natural product synthesis employing pericyclic reactions | Exercise problems might be given in this class. |
Study advice (preparation and review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
DAIGAKUIN-KOUGI II –Organic Chemistry– (ISBN 9784807908219)
Pericyclic Reactions Ian Fleming
Reference books, course materials, etc.
DAIGAKUIN-KOUGI II –Organic Chemistry– (Exercise problems)
Frontier Orbitals and Organic Chemical Reacctions, Ian Fleming
Evaluation methods and criteria
Students’ course scores are based on exercise problems and reports.
Related courses
- CHM.D331 ： Organic Synthesis
- CHM.D401 ： Basic Concepts of Organic Chemistry
- CHM.D201 ： Organic Chemistry I
- CHM.D202 ： Organic Chemistry II
- CHM.D301 ： Organic Chemistry III
Prerequisites
Students require basic knowledge of organic chemistry.