2021 Faculty Courses School of Science Department of Chemistry Graduate major in Chemistry
Advanced Organic Synthesis
- Academic unit or major
- Graduate major in Chemistry
- Instructor(s)
- Ken Ohmori
- Class Format
- Lecture
- Media-enhanced courses
- -
- Day of week/Period
(Classrooms) - 3-4 Mon / 3-4 Thu
- Class
- -
- Course Code
- CHM.D432
- Number of credits
- 200
- Course offered
- 2021
- Offered quarter
- 2Q
- Syllabus updated
- Jul 10, 2025
- Language
- English
Syllabus
Course overview and goals
In early part of this course, the basic concept of retorsynthesis will be focused, and the latter half part will deal with several examples of multistep synthesis, particularly introducing synthetic approaches to natural products.
Course description and aims
At the end of this course, students will be able to have an understanding of basic concept of retrosynthesis and to learn about various synthetic tactics and strategies, enabling access to complex natural products.
Keywords
multistep synthesis
retrosynthesis
natural product synthesis
Competencies
- Specialist skills
- Intercultural skills
- Communication skills
- Critical thinking skills
- Practical and/or problem-solving skills
Class flow
Attendance is taken in every class.
Course schedule/Objectives
| Course schedule | Objectives | |
|---|---|---|
| Class 1 | basic concept of retrosynthesis | Exercise problems might be given in this class. |
| Class 2 | functional group transformation in retrosynthesis | Exercise problems might be given in this class. |
| Class 3 | addition of a functional group for retrosynthesis | Exercise problems might be given in this class. |
| Class 4 | migratory functional group introduction in retrosynthesis | Exercise problems might be given in this class. |
| Class 5 | rearrangement concept in retrosynthesis | Exercise problems might be given in this class. |
| Class 6 | retrosynthesis based on cascade bond formation mechanism | Exercise problems might be given in this class. |
| Class 7 | retrosynthesis for chiral compounds | Exercise problems might be given in this class. |
| Class 8 | synthesis of caryophyllene | Exercise problems might be given in this class. |
| Class 9 | synthesis of cubane | Exercise problems might be given in this class. |
| Class 10 | synthesis of thromboxane A2 | Exercise problems might be given in this class. |
| Class 11 | synthesis of 1β-methyl carbapenem antibiotic | Exercise problems might be given in this class. |
| Class 12 | synthesis of ginkgolide | Exercise problems might be given in this class. |
| Class 13 | synthesis of taxol | Exercise problems might be given in this class. |
| Class 14 | synthesis of FK506 | Exercise problems might be given in this class. |
| Class 15 | Exercise for application problems | Exercise problems might be given in this class. |
Study advice (preparation and review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
DAIGAKUIN-KOUGI II –Organic Chemistry– (ISBN 9784807908219)
Reference books, course materials, etc.
DAIGAKUIN-KOUGI II –Organic Chemistry– (Exercise problems)
Evaluation methods and criteria
Students’ course scores are based on final exams (ca. 70%), which will be held on site (not via online) and exercise problems (ca. 30%).
Related courses
- CHM.D331 ： Organic Synthesis
- CHM.D401 ： Basic Concepts of Organic Chemistry
- CHM.D201 ： Organic Chemistry I
- CHM.D202 ： Organic Chemistry II
- CHM.D301 ： Organic Chemistry III
Prerequisites
Students require basic knowledge of organic chemistry.