2024 Faculty Courses School of Materials and Chemical Technology Undergraduate major in Chemical Science and Engineering
Chemical Science and Engineering Laboratory Ⅳ
- Academic unit or major
- Undergraduate major in Chemical Science and Engineering
- Instructor(s)
- Seiko Kimijima / Teruoki Tago / Shinsuke Mori / Hideyuki Matsumoto / Tetsuo Fuchino / Izumi Taniguchi / Takuya Harada / Ichiro Yamanaka / Kohei Yoshimatsu / Katsunori Tanaka / Masatoshi Tokita / Takeshi Serizawa / Gennichi Konishi / Hidemine Furuya / Kazuko Nakazono / Satoshi Kodama / Kentaro Kimura / Yasuhiko Orita / Keisuke Kameda / Masanori Yamamoto / Kenta Watanabe / Naoki Matsui / Atsunori Ikezawa / Takeyoshi Okajima / Yoshihito Kayaki / Rachmat Pradipta Ambara / Lorenzo Catti / Masato Mitani / Tomohiro Kubo / Naruki Kurokawa / Yuuki Hata / Haonan Liu / Xiaobin Liang / Sergei Manzhos
- Class Format
- Experiment (Face-to-face)
- Media-enhanced courses
- -
- Day of week/Period
(Classrooms) - 5-8 Mon / 5-8 Tue
- Class
- -
- Course Code
- CAP.F304
- Number of credits
- 004
- Course offered
- 2024
- Offered quarter
- 3-4Q
- Syllabus updated
- Mar 14, 2025
- Language
- Japanese
Syllabus
Course overview and goals
[Summary of the course]In this course, laboratory experiments on chemical engineering, electrochemistry, organic chemistry, and polymer chemistry will be instructed for the students, who studied Chemical Science and Engineering Laboratory I, II, and III. The following four themes in these fields are set: (1) “Chemical Engineering 2” for learning distillation, control engineering, and process engineering, (2) “Electrochemistry” for learning basic principles of electrochemical reactions and chemistry on fuel cells, (3) in the theme of "Organic Chemistry" students will synthesize chiral molecules and their optical resolution to learn typical procedures of organic synthesis and analytical methods necessary to determine the structure of products, and (4) “Polymer Chemistry” for learning the synthesis and physical properties of poly(lactic acid) which is a typical biodegradable polymer.
[Aim of the course]Continuing from Chemical Science and Engineering Laboratory I, II, and III, in this course, students will acquire the basic concepts and principles of applied chemistry and experimental research methods by experiencing more practical experiments on chemical engineering, electrochemistry, organic chemistry, and polymer chemistry. In addition, practical thinking skills will be acquired through the writing of experimental reports.
Course description and aims
The goals of this class are as follows.
(1) Basic experimental operations can be applied according to the experimental purpose of each theme.
(2) Be able to summarize experimental procedures, results, and considerations in the form of a general experimental report.
(3) Be able to explain basic concepts, measurement principles, and their applications related to each theme.
(4) Acquire systematic knowledge about experiments and be able to plan safe and productive chemical experiments.
Keywords
[Theme 1] process control, modeling, simulation, process engineering, process design, reaction system design, separation system design, process modeling, process measurement, process control, vapor-liquid equilibrium, theoretical plate number, distillation
[Theme 2] Electron transfer, battery, redox reaction, standard electrode potential, Nernst equation, electrocatalyst
[Theme 3] Alcohol synthesis, esterification reaction, chirality, optical resolution, nuclear magnetic resonance spectrum
[Theme 4] Poly(lactic acid), ring-opening polymerization, biodegradability, thermal property, Polymer crystals, Stress-strain curve
Competencies
- Specialist skills
- Intercultural skills
- Communication skills
- Critical thinking skills
- Practical and/or problem-solving skills
Class flow
In this experiment, students will be divided into four groups and conduct experiments on Theme 1: Chemical engineering (distillation, control, and process engineering), Theme 2: Electrochemistry (basic electrochemistry and fuel cells), Theme 3: Organic chemistry (synthesis and optical resolution of chiral molecules), and Theme 4: Polymer chemistry (polylactic acid: from synthesis to structure, physical properties, and biodegradation). Students will be divided into groups and proceed in order, with exercises and explanations provided in the last session to confirm their understanding.
Course schedule/Objectives
| Course schedule | Objectives | |
|---|---|---|
| Class 1 | (Theme 1) Chemical Engineering Experiment 2: Distillation, Control and Process Engineering] Distillation 1: Start-up operation and stationary state control | Capable of start-up operation and stationary state control |
| Class 2 | (Theme 1) Chemical Engineering Experiment 2: Distillation, Control and Process Engineering] Distillation 2: Concentration measurement and mass balance calculation. Estimation of vapor-liquid equilibrium composition and theoretical plates number. | Measuring concentrations and calculating mass balances. Estimate the vapor-liquid equilibrium composition and calculate the theoretical plates number. |
| Class 3 | (Theme 1) Chemical Engineering Experiment 2: Distillation, Control and Process Engineering] Control 1: Acquire data input/output methods to external devices using Simulink | Acquire data input/output methods to external devices using Simulink |
| Class 4 | (Theme 1) Chemical Engineering Experiment 2: Distillation, Control, and Process Engineering] Control 2: Process modeling by transfer function and process control technology by PID | Acquire process modeling by transfer function and process control technology by PID. |
| Class 5 | (Theme 1) Chemical Engineering Experiment 2: Distillation, Control, and Process Engineering] Process Engineering 1: Reaction System Design by Computer Simulation | Acquire reaction system design methods by computer simulation. |
| Class 6 | (Theme 1) Chemical Engineering Experiment 2: Distillation, Control, and Process Engineering] Process Engineering 2: Separation System Design by Computer Simulation | Acquire separation system design method by computer simulation. |
| Class 7 | (Theme 2) Basic Electrochemistry and Fuel Cells] Basic Electrochemistry Experiment: First Lecture | Understand and explain the outline and basic principles of electrochemistry. |
| Class 8 | (Theme 2) Basic Electrochemistry and Fuel Cells] Basic Electrochemistry Experiment: What is Electric Potential? | Understand and explain redox potential by measuring voltage and potential using a two-pole electrochemical cell. |
| Class 9 | (Theme 2) Basic Electrochemistry and Fuel Cells] Basic Electrochemistry Experiment: Relationship between Electric Potential and Electric Current | Perform cyclic voltammetry (CV) using a tripolar electrochemical cell. Measuring the current produced by potential scanning, understand and explain electrochemical reactions. |
| Class 10 | (Theme 2) Basic Electrochemistry and Fuel Cells] Basic Electrochemistry Experiment: Application of Electrochemical Reactions | Understand and explain the relationship between redox and electrochemical reactions by performing electroless plating and electrolytic plating. |
| Class 11 | (Theme 2) Basic Electrochemistry and Fuel Cells] Fuel Cell Experiments: Lecture and Catalyst Synthesis | Learn about electrochemical applications, and in particular, explain the principle of operation of fuel cells. Acquire the synthesis of platinum-supported catalysts by the liquid-phase reduction method. |
| Class 12 | (Theme 2) Basic Electrochemistry and Fuel Cells] Fuel Cell Experiment: CV Measurement and Fuel Cell Evaluation | Derive Pt/C catalyst particle size from CV measurements. Fabricate a hydrogen/oxygen fuel cell and measure the electromotive force (EMF). Understand and quantify electrocatalyst analysis and fuel cell characterization methods. |
| Class 13 | (Theme 3) Synthesis and Optical Resolution of Chiral Molecules】Initial lecture: Students will learn the basics of organic stereochemistry and the instrumental analysis methods used in this experiment. | Understand and explain the basic properties of chiral molecules and their analytical methods. |
| Class 14 | (Theme 3) Synthesis and optical resolution of chiral molecules: Synthesis of chiral alcohols by reduction of carbonyl compounds. Unit operation: Inert gas substitution, heat reflux, and solvent distillation | Acquire a typical procedure for reduction reaction operated under an inert gas atmosphere. |
| Class 15 | (Theme 3) Synthesis and optical resolution of chiral molecules: Synthesis of optically active esters by kinetic resolution of racemic alcohols. Unit operation: TLC and solvent distillation | Understand the principles of asymmetric reactions and be able to perform the necessary reaction operations. |
| Class 16 | (Theme 3) Synthesis and optical resolution of chiral molecules: Purify a single compound from multiple products by column chromatography. Unit operation: column chromatography, TLC, and solvent distillation | Understand chromatographic operations and be able to isolate pure target products. |
| Class 17 | (Theme 3) Synthesis and optical resolution of chiral molecules: Practice identification of products by spectroscopic methods. Analytical equipment: Nuclear magnetic resonance spectrometer | Analyze nuclear magnetic resonance spectra and determine the structure of compounds |
| Class 18 | (Theme 3) Synthesis and Optical Resolution of Chiral Molecules: Determine the optical purity of chiral compounds. Analysis equipment: High-performance liquid chromatography, polarimeter | Understand the principles of the method for determining the ratio of optical isomers and be able to quantify optical purity. |
| Class 19 | (Theme 4) Poly(lactic acid): From Synthesis to Structure, Physical Properties, and Biodegradability] Synthesis of Poly(lactic acid) by Ring-Opening Polymerization | Ring-opening polymerization of lactide. |
| Class 20 | (Theme 4) Poly(lactic acid): From Synthesis to Structure, Physical Properties, and Biodegradability] Molecular weight evaluation and film formation of poly(lactic acid) | Acquire the evaluation method for the molecular weight of polymer by GPC measurement, the preparation of films, and degradation tests of poly(lactic acid). |
| Class 21 | (Theme 4) Poly(lactic acid): From Synthesis to Structure, Physical Properties, and Biodegradability] Structure and physical properties of poly(lactic acid): Thermal property measurement and chemical structure analysis | Acquire thermal property evaluation method by DSC measurement and chemical structure analysis by NMR measurement. |
| Class 22 | (Theme 4) Poly(lactic acid): From Synthesis to Structure, Physical Properties, and Biodegradability] Structure and physical properties of poly(lactic acid): Spherical crystal observation and X-ray diffraction | Learn how to observe spherical crystals using a polarization microscope. |
| Class 23 | (Theme 4) Poly(lactic acid): From Synthesis to Structure, Physical Properties, and Biodegradability] Structure and physical properties of poly(lactic acid): Evaluation of mechanical properties | Acquire the operation of tensile tester and evaluation method of mechanical properties of polymer films. |
| Class 24 | (Theme 4) Poly(lactic acid): From Synthesis to Structure, Physical Properties, and Biodegradability] Structure and physical properties of poly(lactic acid): Degradability evaluation of poly(lactic acid) | Acquire methods for evaluating the degradability of polylactic acid. |
Study advice (preparation and review)
To enhance effective learning, students are encouraged to spend a certain length of time outside of class on preparation and review (including for assignments), as specified by the Tokyo Institute of Technology Rules on Undergraduate Learning (東京工業大学学修規程) and the Tokyo Institute of Technology Rules on Graduate Learning (東京工業大学大学院学修規程), for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
Textbook for the Chemical Science and Engineering Laboratory IV (In Japanese), edited by the committee for the chemical science and engineering laboratory (Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering). Students should buy the textbook at Co-op Book Store before the guidance.
Reference books, course materials, etc.
化学同人編集部著 『続 実験を安全に行うために―基本操作・基本測定編―』 第4版（化学同人）ISBN: 978-4-7598-1834-5
Evaluation methods and criteria
In principle, full attendance and completion of all experiments are required. Performance will be evaluated based on attitude toward the experiment, including preparation status, experiment report submission status, and scoring results. If you are repeatedly late or submit late, you may be disqualified.
Related courses
- CAP.B201 ： Chemical Engineering and Industrial Chemistry Laboratory I a/b
- CAP.B202 ： Chemical Engineering and Industrial Chemistry Laboratory I b/a
- CAP.B203 ： Chemical Engineering and Industrial Chemistry Laboratory II a/b
- CAP.B204 ： Chemical Engineering and Industrial Chemistry Laboratory II b/a
- CAP.B305 ： Chemical Engineering and Industrial Chemistry Laboratory III
- CAP.F205 ： Chemical Science and Engineering LaboratoryⅠ
- CAP.F206 ： Chemical Science and Engineering LaboratoryⅡ
- CAP.F301 ： Chemical Science and Engineering Laboratory Ⅲ
- CAP.F302 ： Chemical Engineering and Industrial Chemistry Laboratory IV a/b
- CAP.F303 ： Chemical Engineering and Industrial Chemistry Laboratory IV b/a
Prerequisites
Students must have successfully completed both Chemical Science and Engineering Laboratory I (CAP.F205R) and Chemical Science and Engineering Laboratory II (CAP.F206R) or Chemical Engineering and Industrial Chemistry Laboratory I a/b & b/a (CAP.B201.R, CAP.B202.R) and Chemical Engineering and Industrial Chemistry Laboratory II a/b & b/a (CAP.B203.R, CAP.B204.R).
Other
Related courses of each theme:
【Theme１】CAP.G201 ： Chemical Engineering Basics, CAP.G202 ： Chemical Engineering I (Phase & Interface Engineering), CAP.G203 ： Chemical Engineering II (Molecular Diffusion), CAP.G205 ： Chemical Engineering III (Transport Phenomena Basics), CAP.G302 ： Transport Phenomena Engineering (Fluid dynamics ･Heat Transfer), CAP.G304 ： Computational Chemical Engineering, CAP.G305 ： Separation Engineering I (Fluid Phase System), CAP.G307 ： Process Control Engineering, CAP.G308 ： Chemical Process Design
【Theme２】CAP.H301 ： Electrochemistry I (Basics), CAP.H302 ： Electrochemistry II (Advanced)
【Theme３】CAP.O201 ： Organic Chemistry I(Alkanes, Alkenes, Alkynes), CAP.O202 ： Organic Chemistry II(C-X), CAP.O203 ： Organic Chemistry III(Benzene・C-O), CAP.O204 ： Organic Chemistry IV（C=O・C≡N), CAP.O305 ： Practical Organic Chemistry (Synthesis Implementation), CAP.O303 ： Instrumental Analysis (Advanced Organic Molecular Spectrum Analysis)
【Theme４】CAP.Y201 ： Polymer Chemistry Basics, CAP.Y203 ： Polymer Synthesis II (Chain Polymerizaiton), CAP.Y205 ： Polymer Physics II (Solid Structures)