2023 Faculty Courses School of Materials and Chemical Technology Department of Chemical Science and Engineering Graduate major in Chemical Science and Engineering

Frontiers of Chemical Science and Engineering I

Academic unit or major: Graduate major in Chemical Science and Engineering
Instructor(s): Katsuhiko Tomooka / Hirohisa Ohmiya
Class Format: Lecture (HyFlex)
Media-enhanced courses: -
Day of week/Period (Classrooms): Intensive
Class: -
Course Code: CAP.T423
Number of credits: 100
Course offered: 2023
Offered quarter: 3-4Q
Syllabus updated: Jul 8, 2025
Language: Japanese

Syllabus

Course overview and goals

[Outline] In this lecture, we will comprehend the fundamental properties and reactivities of substances at the atomic / molecular level, advanced chemical technology systems on the design and conversion of useful substances including macromolecules, and chemistry In order to train people, researchers active at the forefront of Applied Chemistry field introduce research results from basic to applied.
[Objective] We aim to acquire a broad knowledge of researchers who are active at the forefront of applied chemistry field concerning research from basic to applied.

Course description and aims

Learn the following abilities by taking this lecture.
(1) It can explain basic properties and reactivity of substances at atomic / molecular level. (2) Explain the advanced chemical technology system on the design and conversion of useful substances. (3) Explain a wide range of knowledge from basic to applied research.

Keywords

Basic properties, atoms / molecules, materials, chemical technology, applied chemistry

Competencies

Specialist skills
Intercultural skills
Communication skills
Critical thinking skills
Practical and/or problem-solving skills

Class flow

Two lecturers will give intensive lectures in a hybrid manner with on-site and zoom for two days each. First half: Dr. Hirohisa Ohmiya : Radicals open up new catalysts, reactions, and functions, and second half: Dr. Katsuhiko Tomooka: Chiral molecular science revisited.

Course schedule/Objectives

	Course schedule	Objectives
Class 1	1-1 Manufacturing at the molecular level: Organic synthesis (1) This lecture will introduce the connection between organic synthesis and daily life. 1-2 Manufacturing at the molecular level: Organic synthesis (2) This lecture will introduce the fascination of organic synthesis with the explanations of Nobel prize reactions such as Pd-catalyzed cross couplings (2010), asymmetric hydrogenation/oxidation (2001), and asymmetric organocatalysts (2021). 1-3 Radicals open up new catalysts, reactions, and functions This lecture will introduce our recent achievements on the creation of new catalysts, reactions, and functions by utilization of radicals. 2-1. Planning synthetic strategies and practical retrosynthetic analysis This lecture will introduce the basics of retrosynthetic analysis including synthon, functional group interconversion, latent polarity, umpolung/retron, precursor, and transform. 2-2 Practical reaction developments This lecture will introduce actual examples of reaction developments such as C-C bond formation, oxidation, reduction, and cycloaddition reactions. 2-3 Chiral molecular science revisited This lecture will introduce our studies on "unnatural chiral molecules" especially on chiral silicon molecules and planar chiral heterocyclic molecules, and the principle and examples of a new method "Dynamic Asymmetry Induced Synthesis (DYASIN)" to obtain chiral molecules as optically active materials.	(1)Can explain the characteristics of Pd-catalyzed cross couplings, asymmetric hydrogenation/oxidation, and asymmetric organocatalysts. (2)Can explain trends in reaction chemistry using radicals. (3)Can explain the basics on organic synthetic strategies. (4)Can explain the outline of unnatural chiral molecules.

Course schedule

Objectives

Class 1

1-1 Manufacturing at the molecular level: Organic synthesis (1)
This lecture will introduce the connection between organic synthesis and daily life.

1-2 Manufacturing at the molecular level: Organic synthesis (2)
This lecture will introduce the fascination of organic synthesis with the explanations of Nobel prize reactions such as Pd-catalyzed cross couplings (2010), asymmetric hydrogenation/oxidation (2001), and asymmetric organocatalysts (2021).

1-3 Radicals open up new catalysts, reactions, and functions
This lecture will introduce our recent achievements on the creation of new catalysts, reactions, and functions by utilization of radicals.

2-1. Planning synthetic strategies and practical retrosynthetic analysis
This lecture will introduce the basics of retrosynthetic analysis including synthon, functional group interconversion, latent polarity, umpolung/retron, precursor, and transform.

2-2 Practical reaction developments
This lecture will introduce actual examples of reaction developments such as C-C bond formation, oxidation, reduction, and cycloaddition reactions.

2-3 Chiral molecular science revisited
This lecture will introduce our studies on "unnatural chiral molecules" especially on chiral silicon molecules and planar chiral heterocyclic molecules, and the principle and examples of a new method "Dynamic Asymmetry Induced Synthesis (DYASIN)" to obtain chiral molecules as optically active materials.

(1)Can explain the characteristics of Pd-catalyzed cross couplings, asymmetric hydrogenation/oxidation, and asymmetric organocatalysts.

(2)Can explain trends in reaction chemistry using radicals.

(3)Can explain the basics on organic synthetic strategies.

(4)Can explain the outline of unnatural chiral molecules.

Study advice (preparation and review)

Textbook(s)

None required.

Reference books, course materials, etc.

None

Evaluation methods and criteria

Attendance will be checked in every class. Full attendance is required in principle. Course score will be based on the reports evaluation.

Related courses

CAP.A423 ： Advanced Organic Synthesis I
CAP.A424 ： Advanced Organic Synthesis II
CAP.T431 ： Advanced Organometallic Chemistry and Catalysis I
CAP.T432 ： Advanced Organometallic Chemistry and Catalysis II
CAP.I439 ： Advanced Organometallic Chemistry and Catalysis
ENR.H415 ： Introduction to Organic Electrochemistry
CAP.A521 ： Advanced Molecular Design for Organic Synthesis I
CAP.I533 ： Advanced Strategic Organic Synthesis

Prerequisites

No prerequisites.

Other

Schedule
1st lecture: October 3 (Tue), 10:45-17:05 (On-site: Suzukakedai, Zoom: Ookayama)
2nd lecture: November 14 (Tue), 10:45-17:05 (On-site: Ookayama, Zoom: Suzukakedai)