2020 Faculty Courses School of Materials and Chemical Technology Undergraduate major in Chemical Science and Engineering
Advanced Organic Chemistry V (Drug Design and Synthesis)
- Academic unit or major
- Undergraduate major in Chemical Science and Engineering
- Instructor(s)
- Hiroshi Tanaka / Junichiro Yamaguchi / Sinichi Takanashi / Takamitsu Hosoya / Yukari Fujimoto
- Class Format
- Lecture (Zoom)
- Media-enhanced courses
- -
- Day of week/Period
(Classrooms) - 5-8 Wed (S423)
- Class
- -
- Course Code
- CAP.A335
- Number of credits
- 100
- Course offered
- 2020
- Offered quarter
- 3Q
- Syllabus updated
- Jul 10, 2025
- Language
- Japanese
Syllabus
Course overview and goals
[Summary of the lecture] In this lecture, the importance of pharmaceutial and agrochemical sciences will be taught for the students who studied Advanced Organic Chemistry I - IV.
[Aim of the lecture] The stereochemistry is important in understanding biochemistry and essential to analyze the mechanism of various biologically activity of organic compounds. Students understand phenomena of optical and biologically activities of molecules and then the synthesis of biologically activite molecules based on the development of stereoselective organic reactions.
Course description and aims
By the end of this course, students acquire the ability:
(1) Ability to explain the importance of pharmaceutials and agrochemicals.
(2) Ability to explain the molecular design of biologically active compounds.
(3) Ability to explain the development of stereoselective reactions for the synthesis of biologically active compounds.
Keywords
pharmaceuticals, agrochemicals, optical activity, biological activity, stereoselective reactions, physiological mechanisms
Competencies
- Specialist skills
- Intercultural skills
- Communication skills
- Critical thinking skills
- Practical and/or problem-solving skills
Class flow
This lecture will proceed in the following order: (1) development of stereoselective synthetic reactions and synthesis of biological active molecules, (2) development of molecular probes and exploitation of the drug target, (3) natural products and development of bio-probes, (4) molecular biology and clinical medicine.
Course schedule/Objectives
| Course schedule | Objectives | |
|---|---|---|
| Class 1 | Optical Activity and Biological Activity | Explain an optical activity and biological activity. |
| Class 2 | Development of Stereoselective Reactions and Synthesis of Biologically Active Molecules | Explain development of stereoselective organic reactions. |
| Class 3 | Development of probes and Exploitation of Drug Targets | Understand the importance of new probe targeted for new protein. |
| Class 4 | Exploitation of Target Protein and Inhibitory Activity | Understand the importance of targeting proteins and finding inhibitors thereof. |
| Class 5 | Natural Products and Bio-Probes | Understand the importance of atural product bank and bio-probe thereof. |
| Class 6 | Chemical Biology | Understand the importance of chemical biology (interface of organic chemistry and biology). |
| Class 7 | Molecular Biology | Understand the importance of molecular biology for drug design. |
| Class 8 | Molecular Biology（２） | Understand the importance of molecular biology for drug design. |
Study advice (preparation and review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
Not specified.
Reference books, course materials, etc.
Not specified.
Evaluation methods and criteria
Practice problems and interpretation for confirming the level of understanding (85%), level of class participation (15%).
Related courses
- CAP.A231 ： Advanced Organic Chemistry I (Organic Reactions)
- CAP.A332 ： Advanced Organic Chemistry II (Organic Reactions)
- CAP.A333 ： Advanced Organic Chemistry III (Structure and Function)
- CAP.A334 ： Advanced Organic Chemistry IV (Organic Synthesis)
Prerequisites
The condition of the study will not be made, but it is desirable to study Advanced Organic Chemistry I - IV.